A NOVEL CELL-BASED SCREEN IDENTIFIES CHEMICAL ENTITIES THAT REVERSE THE IMMUNE-ESCAPE PHENOTYPE OF METASTATIC TUMOURS

A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours

Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system.When these essential components are lacking, cancers develop the ability to subvert host immune surveillance allowing cancer cells t

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IMPACT OF THE DEFICIT OF PROFESSIONAL DRIVERS ON THE DEVELOPMENT OF TRANSPORT ENTERPRISES FROM RURAL AREAS OF THE WEST POMERANIAN PROVINCE

The aim of the article is to present and evaluate the effects of the deficit of professional drivers and changes in remuneration on the activities and development opportunities of road freight transport enterprises from rural areas of Western Pomerania.To achieve this objective, literature analysis, comparative analysis and elements of descriptive

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